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KMID : 0882419930440020203
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Korean Journal of Medicine
1993 Volume.44 No. 2 p.203 ~ p.220
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Correlation of Tissue Carcinoembryonic Antigen Concentraions and DNA Ploidy in Gastroinestinal Cancers
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정현용
김병호/성자원/허승식/이기천/이헌영/김영건/노승무/윤완희
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Abstract
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ackground : This study was performed to obtain additional information about intratumor
heterogeneity and prognosis of gastrointestinal cancers, as defined by different DNA stemlines
in relation to tumor CEA expression and clinicopathologic characteristics.
Methods : In 26 patients with stomach cancer and 14 patients with colorectal cancer,
carcinoembryonic antigen concentrations in tissue extracts were measured by
radioimmunoassay and the DNA ploidy patterns of same specimens were determined by flow
cytometry.
Result :
1) Mean tissue CEA concentrations in the normal gastric mucosa of the patients with
stomach cancers was 10.2 ng/gm. Tissue CEA concentrations (mean 42.1 ng/gm) of stomach
cancers were 4 times higher than the normal mucosa (p<0.05), significantly correlated to
TNM stages.
2) Tissue CEA concentrations (mean 27.3 ng/gm) in the normal colonic mucosa of the
patients with colorectal cancers were higher levels than normal gastric mucosa (p<0.05).
Tissue CEA concentrations (mean 164.0 ng/gm) of colorectal cancers were 6 times higher
than the colorectal mucosa' and 4 times higher than stomach cancer's (p<0.05).
3) The incidence of aneuploid pattern in the stomach cancer was 44.0%, and 25.0% in the
colorectal cancers. The incidence of anequploid cancer was not significantly related to
clinicopathologic findings.
4) Tissue CEA concentrations of anequploid stomach cancers (mean 86.4 ng/gm) were 6
times higher than diploid cancers (mean 14.5 ng/gm) (p<0.05). Aneuploid colorectal cancers
(mean 244.8 ng/gm) had higher CEA levels than diploid cancers (161.7 ng/gm) (p>0.05).
Conclusion : The production of carcinoembryonic antigen in gastrointestinal cancers was
significantly correlated with aneuploid DNA stemlines. To estimate prognostic values of
tissue CEA concentrations and DNA ploidity, follow up for these patients and further studies
should be pursued.
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KEYWORD
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